This is the second of three JMHS papers on implementation of different aspects of the Global Compact on Safe, Orderly and Regular Migration (GCM) and the Global Compact on Refugees (GCR). The papers have been produced by three think-tanks – the Scalabrini Migration Center (SMC) in Manila, covering the Asia-Pacific region, the Scalabrini Institute for Human Mobility in Africa (SIHMA) in Cape Town, and the Center for Migration Studies of New York (CMS). This paper from SIHMA examines the prospects for implementation of the GCR in sub-Saharan Africa. It argues that, given increases in the number of forcibly displaced people in recent years, responses to refugee crises need to shift from a humanitarian system of “care and maintenance,” to more comprehensive and effective development responses. It discusses how best to promote a resilience-based development approach. It recognizes that many development initiatives that have been implemented or that still need to be implemented under the normative framework of the GCR and the Comprehensive Refugee Response Framework (CRRF), are subject to a multiyear planning and implementation cycle. Therefore, the article does not seek to evaluate their efficacy or measure their progress. Rather, it identifies key challenges and it highlights achievements and promising initiatives in sub-Saharan Africa. It particularly focuses on implementation and rollout of the CRRF in Chad, Djibouti, Ethiopia, Kenya, Rwanda, Somalia, Uganda, and Zambia in Africa.